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  4. Ozan Akkus

Ozan Akkus, PhD

OMEGA Principal Investigator
Kent H. Smith Professor
Department of Mechanical and Aerospace Engineering
Case School of Engineering

Research Information

Research Interests

Creates biologically active and mechanically functional tissue repair systems, and develops chemical imaging instrumentation for noninvasive biomedical and hazard diagnostics.

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Publications

  • Collier, C., Hausman, B., Zulqadar, S., Din, E., Anderson, J., Akkus, O., & Greenfield, E. (2020). Characterization of a reproducible model of fracture healing in mice using an open femoral osteotomy. Bone Reports, 12
  • Isali, I., McClellan, P., Shankar, E., Gupta, S., Jain, M., Akkus, O., & Hijaz, A. (2020). PD27-05 POLARIZATION OF MACROPHAGES FROM M0 TO M2 WHEN SEEDED UPON GENIPIN-CROSSLINKED COLLAGEN MESH FOR TREATMENT OF STRESS URINARY INCONTINENCE. The Journal of Urology, 203 , e550-e551.
  • Yang, S., Sen, C., Thompson, R., Zhou, J., & Akkus, O. (2020). An in vitro Raman study on compositional correlations of lipids and protein with animal tissue hydration. Vibrational Spectroscopy, 107
  • Jung, H., & Akkus, O. (2020). Diffuse microdamage in bone activates anabolic response by osteoblasts via involvement of voltage-gated calcium channels. Journal of Bone and Mineral Metabolism, 38 (2), 151-160.
  • Unal, M., Uppuganti, S., Timur, S., Mahadevan-Jansen, A., Akkus, O., & Nyman, J. (2019). Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone. Scientific Reports, 9 (1).
  • Learn, G., McClellan, P., Knapik, D., Cumsky, J., Webster-Wood, V., Anderson, J., Gillespie, R., & Akkus, O. (2019). Woven collagen biotextiles enable mechanically functional rotator cuff tendon regeneration during repair of segmental tendon defects in vivo. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 107 (6), 1864-1876.
  • Younesi, M., Akkus, A., & Akkus, O. (2019). Microbially-derived nanofibrous cellulose polymer for connective tissue regeneration. Materials Science and Engineering C, 99 , 96-102.
  • Zhang, F., Xie, Y., Celik, H., Akkus, O., Bernacki, S., & King, M. (2019). Engineering small-caliber vascular grafts from collagen filaments and nanofibers with comparable mechanical properties to native vessels. Biofabrication, 11 (3).
  • Chapin, K., Khalifa, A., Mbimba, T., McClellan, P., Anderson, J., Novitsky, Y., Hijaz, A., & Akkus, O. (2019). In vivo biocompatibility and time-dependent changes in mechanical properties of woven collagen meshes: A comparison to xenograft and synthetic mid-urethral sling materials: IN VIVO BIOCOMPATIBILITY AND TIME-DEPENDENT CHANGES IN MECHANICAL PROPERTIES. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 107 (3), 479-489.
  • PORTO, T., ROPERTO, R., Akkus, A., Akkus, O., Teich, S., Faddoul, F., PORTO-NETO, S., & CAMPOS, E. (2019). Effect of storage and aging conditions on the flexural strength and flexural modulus of CAD/CAM materials. Dental Materials Journal, 38 (2), 264-270.
  • Unal, M., Akkus, O., Sun, J., Cai, L., Erol, U., Sabri, L., & Neu, C. (2019). Raman spectroscopy-based water content is a negative predictor of articular human cartilage mechanical function. Osteoarthritis and Cartilage, 27 (2), 304-313.
  • Younesi, M., Wu, X., & Akkus, O. (2019). Controlled mercerization of bacterial cellulose provides tunability of modulus and ductility over two orders of magnitude. Journal of the Mechanical Behavior of Biomedical Materials, 90 , 530-537.
  • Du, J., Flanagan, C., Bensusan, J., Knusel, K., Akkus, O., & Rimnac, C. M. (2019). Raman Biomarkers Are Associated with Cyclic Fatigue Life of Human Allograft Cortical Bone. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 101 (17).
  • Learn, G., McClellan, P., Knapik, D., Cumsky, J., Webster-Wood, V., Anderson, J., Gillespie, R., & Akkus, O. (2018). Woven collagen biotextiles enable mechanically functional rotator cuff tendon regeneration during repair of segmental tendon defects in vivo: WOVEN COLLAGEN BIOTEXTILES. Journal of Biomedical Materials Research - Part B Applied Biomaterials.
  • Unal, M., Akkus, O., Sun, J., Cai, L., Erol, U., Sabri, L., & Neu, C. (2018). Raman spectroscopy-based water content is a negative predictor of articular human cartilage mechanical function. Osteoarthritis and Cartilage.
  • Li, B., Singer, N., Rosenthal, A., Unal, M., Haggins, D., Yeni, Y., & Akkus, O. (2018). Chemical characterization of Maltese-cross birefringent particles in synovial fluid samples collected from symptomatic joints. Joint Bone Spine, 85 (4), 501-503.
  • Chapin, K., Khalifa, A., Mbimba, T., McClellan, P., Anderson, J., Novitsky, Y., Hijaz, A., & Akkus, O. (2018). In vivo biocompatibility and time-dependent changes in mechanical properties of woven collagen meshes: A comparison to xenograft and synthetic mid-urethral sling materials: IN VIVO BIOCOMPATIBILITY AND TIME-DEPENDENT CHANGES IN MECHANICAL PROPERTIES. Journal of Biomedical Materials Research - Part B Applied Biomaterials.
  • Amin, A., Sabri, L., Poole, C., Baig, T., Deissler, R., Rindfleisch, M., Doll, D., Tomsic, M., Akkus, O., & Martens, M. (2018). Computational homogenization of the elastic and thermal properties of superconducting composite MgB 2 wire. Composite Structures, 188 , 313-329.
  • Jung, H., Mbimba, T., Unal, M., & Akkus, O. (2018). Repetitive short-span application of extracellular calcium is osteopromotive to osteoprogenitor cells. Journal of Tissue Engineering and Regenerative Medicine, 12 (3), e1349-e1359.
  • Lopes, F., Roperto, R., Akkus, A., Akkus, O., Palma-Dibb, R., & De Sousa-Neto, M. (2018). Effect of laser activated bleaching on the chemical stability and morphology of intracoronal dentin. Archives of Oral Biology, 86 , 40-45.
  • Unal, M., & Akkus, O. (2018). Shortwave-infrared Raman spectroscopic classification of water fractions in articular cartilage ex vivo. Journal of Biomedical Optics, 23 (1).
  • Abraham, Z., Hawley, E., Hayosh, D., Webster-Wood, V., & Akkus, O. (2018). Kinesin and dynein mechanics: measurement methods and research applications. Journal of Biomechanical Engineering, 140 (2).
  • Porto, T., Roperto, R., Akkus, A., Akkus, O., Teich, S., Faddoul, F., Porto-Neto, Sizenando de Toledo, F., & De Campos, Edson Alves, F. (2018). Effect of thermal cycling on fracture toughness of CAD/CAM materials. AMERICAN JOURNAL OF DENTISTRY, 31 (4), 205-210.
  • Unal, M., Cingoz, F., Bagcioglu, C., Sozer, Y., & Akkus, O. (2018). Interrelationships between electrical, mechanical and hydration properties of cortical bone. Journal of the Mechanical Behavior of Biomedical Materials, 77 , 23-Dec.
  • Liu, T., Premasiri, K., Sui, Y., Zhan, X., Mustafa, Haithem A. B., X., Akkus, O., Zorman, C., Gao, Xuan P. A., C., & Sankaran, R. (2018). Direct, Transfer-Free Growth of Large-Area Hexagonal Boron Nitride Films by Plasma-Enhanced Chemical Film Conversion (PECFC) of Printable, Solution-Processed Ammonia Borane. ACS APPLIED MATERIALS & INTERFACES, 10 (50), 43936-43945.
  • Webster-Wood, V., Akkus, O., Gurkan, U., Chiel, H., & Quinn, R. D. (2017). Organismal engineering: Toward a robotic taxonomic key for devices using organic materials. Science Robotics, 2 (12).
  • Li, B., Singer, N., Rosenthal, A., Unal, M., Haggins, D., Yeni, Y., & Akkus, O. (2017). Chemical characterization of Maltese-cross birefringent particles in synovial fluid samples collected from symptomatic joints.. Joint Bone Spine.
  • Akkus, A., Yang, S., Roperto, R., Mustafa, H., Teich, S., & Akkus, O. (2017). A portable fiber-optic raman spectrometer concept for evaluation of mineral content within enamel tissue. Journal of Clinical and Experimental Dentistry.
  • Younesi, M., Knapik, D., Cumsky, J., Donmez, B., He, P., Islam, A., Learn, G., McClellan, P., Bohl, M., Gillespie, R., & Akkus, O. (2017). Effects of PDGF-BB delivery from heparinized collagen sutures on the healing of lacerated chicken flexor tendon in vivo. Acta Biomaterialia, 63 , 200-209.
  • Abraham, Z., Hawley, E., Hayosh, D., Webster-Wood, V., & Akkus, O. (2017). Kinesin and dynein mechanics: measurement methods and research applications. Journal of Biomechanical Engineering.
  • Morris, V., Nimbalkar, S., Younesi, M., McClellan, P., & Akkus, O. (2017). Mechanical properties, cytocompatibility and manufacturability of chitosan: PEGDA hybrid-gel scaffolds by stereolithography. Annals of biomedical engineering, 45 (1), 286–296.
  • Cudjoe, E., Younesi, M., Cudjoe, E., Akkus, O., & Rowan, S. (2017). Synthesis and Fabrication of Nanocomposite Fibers of Collagen-Cellulose Nanocrystals by Coelectrocompaction. Biomacromolecules, 18 (4), 1259-1267.
  • Baig, T., Al Amin, A., Deissler, R., Sabri, L., Poole, C., Brown, R., Tomsic, M., Doll, D., Rindfleisch, M., Peng, X., Mendris, R., Akkus, O., Sumption, M., & Martens, M. (2017). Conceptual designs of conduction cooled MgB 2 magnets for 1.5 and 3.0 T full body MRI systems. Superconductor Science and Technology, 30 (4).
  • Islam, A., Mbimba, T., Younesi, M., & Akkus, O. (2017). Effects of substrate stiffness on the tenoinduction of human mesenchymal stem cells. Acta Biomaterialia.
  • Lopes, F., Roperto, R., Akkus, A., Akkus, O., Palma-Dibb, R., & Sousa-Neto, M. (2017). Laser-activated bleaching effect on intracoronal dentin chemical stability, morphology. Dental Materials, 33 , e1-e2.
  • Flanagan, C., Unal, M., Akkus, O., & Rimnac, C. M. (2017). Raman spectral markers of collagen denaturation and hydration in human cortical bone tissue are affected by radiation sterilization and high cycle fatigue damage. Journal of the Mechanical Behavior of Biomedical Materials, 75 , 314-321.
  • Younesi, M., Donmez, B., Islam, A., & Akkus, O. (2017). Corrigendum to "Heparinized collagen sutures for sustained delivery of PDGF-BB: Delivery profile, effects on tendon-derived cells In-Vitro" [Acta Biomater. 41 (2016) 100–109]. Acta Biomaterialia.
  • Wang, B., Sun, X., Akkus, O., & Wang, L. (2017). Elevated Solute Transport at Sites of Diffuse Matrix Damage in Cortical Bone: Implications on Bone Repair. Journal of Orthopaedic Research.