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Our lab studies molecular and in vivo mechanisms of cardiac regulation. We focus on the role of contractile proteins in modulation of mechanical and hemodynamic function in genetic and aquired heart failure. We use biophysical techniques, in vivo cardiovascular phenotyping, and gene replacement approaches to develop novel therapies that improve contractile function in heart failure.

Our lab focuses on the physiology of mechanosensory cells of the inner ear; receptors for senses of hearing and balance; in mouse and zebrafish models; electrophysiology, optical and electron microscopy imaging.

Our lab studies the structure of engineered adenovirus vectors and their complexes with immune molecules. More specifically we focus on understanding the molecular mechanisms underlying systemic inflammation and how targeted viral capsid mutations might alter host-pathogen interactions. We utilize cryo-electron microscopy (cryo-EM) single particle reconstruction and tomography, molecular dynamics and molecular modeling.

Phoebe L. Stewart's Biography 

We are interested in understanding the functional implications of oral resident memory T cells on various aspects of oral physiology and disease. To address these questions, we utilize mouse models of oral viral infections and oral inflammatory diseases including periodontitis. We are also interested in understanding whether local T-cell driven inflammatory responses in the oral mucosa impact chemosensory biology (e.g., taste and smell). 

J. Michael Stolley's Biography 

My research includes synaptic physiology, hippocampus, olfactory bulb and computational neuroscience. 

Ben W. Strowbridge

My Laboratory is dedicated to the study of cell signaling to develop novel therapies against infectious and inflammatory diseases. This work includes translational studies in animal models of these diseases. 

Our lab studies the function of the hippocampal circuit, a brain area that is vital for memory formation and is linked to many neuropsychiatric disorders, such as PTSD, schizophrenia, and Alzheimer's disease. We use a variety of in vitro and in vivo techniques – including electrophysiology, neuronal tracing, optogenetics and chemogenetics, immunohistochemistry, and mouse behavior – to address the cellular and circuit mechanisms underlying hippocampal information processing and its relevance to behaviors.

Qian Sun's Biography 

I research diseases of protein misfolding, neurodegenerative diseases, amyloid and prion disease, Alzheimer's disease, protein chemistry, protein folding, liquid-liquid phase separation of proteins, protein-membrane interactions, and biophysical chemistry. 

Our lab studies how the brain uses specific coding mechanisms to regulate persistent internal drive. Our lab's goal is to understand how neural coding impacts molecular/cellular signaling, plasticity, and behavior. We apply multidisciplinary approaches in Drosophila to understand how non-canonical (temporal or analog) neural codes represent persistent internal drive. 

Masashi Tabuchi's Biography 

I research the molecular mechanisms of neuroreceptor complexes and synaptic transmission.